The length of the glaciers in the world:a straightforward method for the automated calculation of glacier center lines

Glacier length is an important measure of glacier geometry but global glacier inventories are mostly lacking length data. Only recently semi-automated approaches to measure glacier length have been developed and applied regionally. Here we present a first global assessment of glacier length using a fully automated method based on glacier surface slope, distance to the glacier margins and a set of trade-off functions. The method is developed for East Greenland, evaluated for the same area as well as for Alaska, and eventually applied to all ∼200 000 glaciers around the globe. The evaluation highlights accurately calculated glacier length where DEM quality is good (East Greenland) and limited precision on low quality DEMs (parts of Alaska). Measured length of very small glaciers is subject to a certain level of ambiguity. The global calculation shows that only about 1.5% of all glaciers are longer than 10 km with Bering Glacier (Alaska/Canada) being the longest glacier in the world at a length of 196 km. Based on model output we derive global and regional area-length scaling laws. Differences among regional scaling parameters appear to be related to characteristics of topography and glacier mass balance. The present study adds glacier length as a central parameter to global glacier inventories. Global and regional scaling laws might proof beneficial in conceptual glacier models

Isolated photon and photon+jet production at NNLO QCD accuracy and the ratio R13/8γR_{13/8}^\gamma

We discuss different approaches to photon isolation in fixed-order calculations and present a new next-to-next-to-leading order (NNLO) QCD calculation of $R_{13/8}^\gamma$, the ratio of the inclusive isolated photon cross section at 8 TeV and 13 TeV, differential in the photon transverse momentum, which was recently measured by the ATLAS collaboration.Comment: 4 pages, 1 figure. Contribution to the 2019 QCD session of the 54th Rencontres de Morion

Role-similarity based functional prediction in networked systems: Application to the yeast proteome

We propose a general method to predict functions of vertices where: 1. The wiring of the network is somehow related to the vertex functionality. 2. A fraction of the vertices are functionally classified. The method is influenced by role-similarity measures of social network analysis. The two versions of our prediction scheme is tested on model networks were the functions of the vertices are designed to match their network surroundings. We also apply these methods to the proteome of the yeast Saccharomyces cerevisiae and find the results compatible with more specialized methods

Vertically Aligning Evidence and Argument in the Elementary Education Program

Using classes which are common to the Elementary Education program, assignments will be added in which students must be able to show evidence and be able to argue their ideas. To make sure that all elementary education students can participate in this project, the classes would include: ELED 345, ELED 355, ELED 405, ELED 406, and ELED 407. This would allow the IVS classes which take place in Owensboro, Elizabethtown and Glasgow to also participate. EDU 250 is a class which affects only some of the WKU students (because some students take the course in a local community college before enrolling at WKU) so It has been left out intentionally. This entails meeting with the professors who teach these classes. Often there are at least two different professors who teach each of these classes, and because I only teach one of these classes, it involves meeting with two others for each of the classes listed. I would also discuss the changes with all of the elementary faculty at the Elementary Education meetings held following every monthly School of Teacher Education meeting. ELED 345, ELED 355 and ELED 407 would be the first focus in the Spring 2016 semester. These are the earliest classes in the program. ELED 406 and ELED 405 would follow Fall 2016 since these classes happen in the students’ senior year right before student teaching. Because there is also now a joint program with Special Education in which students in the Special Ed/ELED program take ELED 405, ELED 406, and ELED 407, there would also be a need to visit with the Special Education faculty members for them to see how evidence and argument has been added to their students’ program

Sub-Zero Alteration in an Isotopically Heavy Brine Preserved in a Pristine H Chondrite Xenolith

Introduction: Brecciated H chondrites host a variety of xenoliths, including unshocked, phyllo- silicate-rich carbonaceous chondrites (CCs). The brecciated H chondrite Zag (H3-6) is one of two chondrites to host macroscopic (1 - 5mm), xenolithic crystals of halite (NaCl) with aqueous fluid inclusions and organics. A ~1cm CC xenolith in Zag (Zag clast) has mineralogy similar to CI chondrites, but it has a unique bulk oxygen isotopic composition among all meteorites ((exp 17)O = 1.49 0.04 , (exp 18)O = 22.38 0.17 ). The Zag clast encloses halite in its matrix, linking the coarse, matrix halite and the xenolith to the same parent object, suggested to be hydrovolcanically active. Its bulk C and N contents are the highest among chondrites and bulk (exp 15)N is similar to CR chondrites and Bells. Insoluble organic material (IOM) in the Zag clast has D and (exp 15)N hotspots, also similar to CR chondrites and Bells (C2-ung.). We provide further isotopic characterization of the Zag clast to constrain the formation temperature and origin of its primary and secondary components

Clasts in the CM2 carbonaceous chondrite Lonewolf Nunataks 94101: evidence for aqueous alteration prior to complex mixing

Clasts in the CM2 carbonaceous chondrite Lonewolf Nunataks (LON) 94101 have been characterized using scanning and transmission electron microscopy and electron microprobe analysis to determine their degrees of aqueous alteration, and the timing of alteration relative to incorporation of clasts into the host. The provenance of the clasts, and the mechanism by which they were incorporated and mixed with their host material are also considered. Results show that at least five distinct types of clasts occur in LON 94101, of which four have been aqueously altered to various degrees and one is largely anhydrous. The fact that they have had different alteration histories implies that the main part of aqueous activity occurred prior to the mixing and assimilation of the clasts with their host. Further, the presence of such a variety of clasts suggests complex mixing in a dynamic environment involving material from various sources. Two of the clasts, one containing approximately 46 vol% carbonate and the other featuring crystals of pyrrhotite up to approximately 1 mm in size, are examples of unusual lithologies and indicate concentration of chemical elements in discrete areas of the parent body(ies), possibly by flow of aqueous solutions

Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment.

Objectives: To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site. Methods: Patients with symptoms suggestive of tumour necrosis factor receptor-associated periodic syndrome (TRAPS) and 22 healthy controls (HC) were screened for mutations in the TNFRSF1A gene. Soluble TNFRSF1A and inflammatory cytokines were measured by ELISAs. TNFRSF1A shedding was examined by stimulation of peripheral blood mononuclear cells (PBMCs) with phorbol 12-myristate 13-acetate followed by flow cytometric analysis (FACS). Apoptosis of PBMCs was studied by stimulation with TNFa in the presence of cycloheximide and annexin V staining. T cell phenotypes were monitored by FACS. Results: TNFRSF1A sequencing disclosed a novel V173D/ p.Val202Asp substitution encoded by exon 6 in one family, the c.194–14G.A splice variant in another and the R92Q/p.Arg121Gln substitution in two families. Cardiovascular complications (lethal heart attack and peripheral arterial thrombosis) developed in two V173D patients. Subsequent etanercept treatment of the V173D carriers was highly effective over an 18-month follow-up period. Serum TNFRSF1A levels did not differ between TRAPS patients and HC, while TNFRSF1A cleavage from monocytes was significantly reduced in V173D and R92Q patients. TNFa-induced apoptosis of PBMCs and T-cell senescence were comparable between V173D patients and HC. Conclusions: The TNFRSF1A V173D cleavage site mutation may be associated with an increased risk for cardiovascular complications and shows a strong response to etanercept. T-cell senescence does not seem to have a pathogenetic role in affected patients

ADA Compliance in Online Courses: Free Tools and Resources for Creating an Inclusive Environment for Both Students and Instructors

Online courses must be accessible to students with disabilities, yet instructor training in accessible design is often an afterthought, leading to legal vulnerability and a breakdown in the learning partnership between student and instructor. Based on feedback from faculty members who shared their familiarity with expectations from the American Disabilities Association (ADA) and Section 508 of the Workforce Rehabilitation Act, as well as challenges and perceived barriers, this session demonstrated free tools, practical suggestions, and important design tips for bringing all courses into compliance., even for those instructors with less than sophisticated technological expertise